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Registro Completo |
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Biblioteca(s): |
Embrapa Milho e Sorgo. |
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Data corrente: |
10/11/2011 |
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Data da última atualização: |
28/05/2018 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FASSINI, P. G.; NODA, R. W.; FERREIRA, E. S.; SILVA, M. A.; NEVES, V. A.; DEMONTE, A. |
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Afiliação: |
ROBERTO WILLIANS NODA, CNPMS. |
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Título: |
Soybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Lipids in Health and Disease, v. 10, n. 165, 2011. |
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Idioma: |
Inglês |
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Conteúdo: |
Background: This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin), in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals. Methods: Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9): 1) standard (STD): fed on casein as protein source; 2) hypercholesterolemic (HC): STD plus 1% cholesterol and 0.5% cholic acid; 3) HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day); 4) HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day); 5) HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3) and (4). The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain. Results: A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet. Conclusion: Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin) and the protein (glycinin) were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism. MenosBackground: This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin), in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals. Methods: Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9): 1) standard (STD): fed on casein as protein source; 2) hypercholesterolemic (HC): STD plus 1% cholesterol and 0.5% cholic acid; 3) HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day); 4) HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day); 5) HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3) and (4). The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain. Results: A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet. Conclusion: Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin) and the protein (glycinin) were taken simultaneously. The association was shown not to interact additively, a... Mostrar Tudo |
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Thesagro: |
Soja. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/46059/1/Soybean-glycinin.pdf
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Marc: |
LEADER 02335naa a2200193 a 4500
001 1905555
005 2018-05-28
008 2011 bl uuuu u00u1 u #d
100 1 $aFASSINI, P. G.
245 $aSoybean glycinin improves HDL-C and suppresses the effects of rosuvastatin on hypercholesterolemic rats.$h[electronic resource]
260 $c2011
520 $aBackground: This study was an investigation of the effects of ingesting a daily dose of isolated glycinin soy protein (11S globulin), in association with rosuvastatin, on the control of hypercholesterolemia in experimental animals. Methods: Male Wistar rats were kept in individual cages under appropriate controlled conditions of temperature, light and humidity. The animals were divided into five groups (n = 9): 1) standard (STD): fed on casein as protein source; 2) hypercholesterolemic (HC): STD plus 1% cholesterol and 0.5% cholic acid; 3) HC+11S: hypercholesterolemic + glycinin (300 mg/kg/day); 4) HC+ROS: hypercholesterolemic + rosuvastatin (10 mg/kg/day); 5) HC+11S+ROS: HC diet, the 11S protein and the drug in the doses given in (3) and (4). The protein and the drug were administered by gavage for 28 days. The results indicated that the addition of 1% cholesterol and 0.5% cholic acid induced hypercholesterolemia in the animals without interfering with their weight gain. Results: A single daily dose of glycinin contributed an additional 2.8% of dietary protein intake and demonstrated its functional role, particularly in raising HDL-C, decreasing triglycerides in the liver and improving the atherogenic index in animals exposed to a hypercholesterolemic diet. Conclusion: Most of the beneficial effects of the isolated treatments disappeared when the drug (rosuvastatin) and the protein (glycinin) were taken simultaneously. The association was shown not to interact additively, as noted in the plasma levels of total cholesterol and non-HDL cholesterol, and in the significant increase of cholesterol in the liver. Studies are in progress to identify the effects of peptides derived from the 11S globulin and their role in cholesterol metabolism.
650 $aSoja
700 1 $aNODA, R. W.
700 1 $aFERREIRA, E. S.
700 1 $aSILVA, M. A.
700 1 $aNEVES, V. A.
700 1 $aDEMONTE, A.
773 $tLipids in Health and Disease$gv. 10, n. 165, 2011.
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Registro original: |
Embrapa Milho e Sorgo (CNPMS) |
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Biblioteca |
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Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
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Registro Completo
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Biblioteca(s): |
Embrapa Amazônia Oriental. |
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Data corrente: |
30/09/1998 |
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Data da última atualização: |
27/09/2012 |
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Autoria: |
CHENG, S. S.; CARVALHO, J. E. U. de; SOUZA, V. A. B. de; OLIVEIRA, W. M. S. de. |
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Afiliação: |
SIMON SUHWENG CHENG, CPATU; JOSE EDMAR URANO DE CARVALHO, CPATU; VALDOMIRO AURÉLIO BARBOSA DE SOUZA, BOLSISTA CNPQ/CPATU; WALNICE MARIA S. DE OLIVEIRA, BOLSISTA CNPQ/CPATU. |
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Título: |
Comportamento de cultivares e linhagens de abobora (C. mochata Duch) e híbridos interespecíficos (C. maxima x C. mochata) em Belém, na Amazônia Oriental. |
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Ano de publicação: |
1986 |
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Fonte/Imprenta: |
In: SIMPÓSIO DO TRÓPICO ÚMIDO, 1., 1984, Belém, PA. Anais. Belém, PA: EMBRAPA-CPATU, 1986. v. 3, p. 307-309. |
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Série: |
(EMBRAPA-CPATU. Documentos, 36). |
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Idioma: |
Português |
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Notas: |
v.3 Culturas temporárias. |
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Palavras-Chave: |
Hibridação interespecífico. |
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Thesagro: |
Abóbora; Produtividade; Variedade. |
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Thesaurus NAL: |
interspecific hybridization; pumpkins; varieties; yields. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/66994/1/CPATU-Doc36-v3P307.pdf
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Marc: |
LEADER 00925naa a2200265 a 4500
001 1394638
005 2012-09-27
008 1986 bl uuuu u00u1 u #d
100 1 $aCHENG, S. S.
245 $aComportamento de cultivares e linhagens de abobora (C. mochata Duch) e híbridos interespecíficos (C. maxima x C. mochata) em Belém, na Amazônia Oriental.
260 $c1986
490 $a(EMBRAPA-CPATU. Documentos, 36).
500 $av.3 Culturas temporárias.
650 $ainterspecific hybridization
650 $apumpkins
650 $avarieties
650 $ayields
650 $aAbóbora
650 $aProdutividade
650 $aVariedade
653 $aHibridação interespecífico
700 1 $aCARVALHO, J. E. U. de
700 1 $aSOUZA, V. A. B. de
700 1 $aOLIVEIRA, W. M. S. de
773 $tIn: SIMPÓSIO DO TRÓPICO ÚMIDO, 1., 1984, Belém, PA. Anais. Belém, PA: EMBRAPA-CPATU, 1986.$gv. 3, p. 307-309.
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Registro original: |
Embrapa Amazônia Oriental (CPATU) |
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